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This article is the first to have drawn attention to the possible role of brain hypoxia in migraine pathogenesis
Biochem Biophys Res Commun 232:418421
Polyunsaturated fatty acids undergo nonenzymatic peroxidation when oxygen radicals generated by mitochondrial ROS production remove a hydrogen atom from the lipid, resulting in a lipid radical that can propagate to generate more peroxyl/alkoxyl radicals and hydroperoxide [83]
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Supplementary Figs
Additionally, the study highlighted the involvement of the phosphatase and tensin homolog (PTEN)/Akt/NO signaling pathway in the protective effects (Li J
