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Since these aggregate peaks were even observed for diluted samples, the peaks were considered to be derived from irreversible aggregations

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doi: 10.1074/jbc.271.21.12322

Fahrig M

In fact, because it was overly simplistic and poorly worded, it had the opposite effect, she continued

The second mutation, which, in combination with p.C282Y, is responsible for another 5% of HC cases is p.H63D (substitution of histidine instead of aspartame)