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5-Amino-1MQ inhibits this enzyme, forcing cells back into fat oxidation mode

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19 ImaiH.NarashimaK.AraiM.SakamotoH.ChibaN.NakagawaY

10.1038/s41589-021-00808-4

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In most aerobic cells, the tripeptide -Glu-Cys-Gly, known as glutathione (GSH), is the major nonprotein thiol that undergoes oxidation to its corresponding disulfide form (GSSG), and GSH is highly abundant in cells, with its concentration ranging from 0.1 to 10 mM