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The study involved more than 27,000 adults enrolled in the Environmental Predictors of Cognitive Health and Aging study

In previous reports of patients with breast cancer receiving taxanes, SNPs in CYP2C8 and CYP3A4 were identified as causes of grade 2 CIPN [68, 70, 71]

10.1016/j.jot.2025.07.003 47 Jin JungY.ChoiH.OhE

10.1161/CIRCRESAHA.118.314665 53 Eloisa AparecidaV.-B.Davidson CorreaA.Letcia PratesR.FernandaO.ngelo RafaelC

It has been well established that when human OPCs (hOPCs) or glial progenitor cells (hGPCs) are transplanted into mouse models, they demonstrate remarkable potential to restore myelin with some species-specific kinetics

We utilize this system to investigate the effect of the microbiome and aging on APAP toxicity, two variables that have proven difficult to definitively investigate in human or murine systems