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Collectively, multifunctional metabolic enzymes act as pivotal hubs linking metabolic reprogramming to therapeutic resistance, serving as upstream initiators of signaling cascades that drive drug tolerance in CRC
Although the exact underlying mechanisms remain unclear, the neuroinflammation induced by SARS-CoV-2 and its long-term impact on the brain are currently key focuses of research [48]
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Moreover, endocannabinoids are known to exert an important regulatory role in the biology of skin appendages [31]
