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JNCI: J

Class I includes HDAC1, 2, 3, and 8, which are usually localized in the nucleus, have deacetylase activity, and contain zinc-dependent active sites ( + as a cofactor ( Table 1 ) ( Figure 1 ) ( Table 1 Classification of HDACs based on homology to human yeast homologs and generalization of their cofactor, size, and cellular localization

It is primarily studied for its ability to upregulate telomerase activity, the enzyme responsible for rebuilding telomeres (the protective caps at the ends of chromosomes)

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Allometric scaling (multiplying rodent dose by 0.162 for human equivalence) suggests a 70kg human equivalent of approximately 4.5mg

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