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There are interesting similarities in the role of the UPS in SCI and AD although these neurological conditions differ in etiology, age at onset, and region of the central nervous system (CNS) affected

Sulfonaminopyrimidine derivatives that selectively targets CTPS1 can induce apoptosis at nanomolar concentration in cell based assay (Figure 3H) (Quddus, 2020)

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Globally, the mean age of natural menopause is 48.8 years, with remarkably little geographic variation

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