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However, these adducts were found with low absolute abundance compared to free cysteine (alkylated)

The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

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To find the biological relevance of the differentially expressed proteins, we determined the canonical pathways that map to these proteins (Table 6)

10.1038/cddis.2014.506 17 CoppleI