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diseases of the liver, kidneys and the blood (such as leukaemia) can be considered potential reasons for an increased B12 blood level (1-4)

Org Biomol Chem 13:38823886

Hallmarks of Cancer: The Next Generation

The time it takes to feel refreshed after receiving a B12 shot can vary depending on your individual health, lifestyle, and the severity of your deficiency

Journal of Medicinal Chemistry (ACS) Bisubstrate inhibitors of NNMT with enhanced activity PMC NNMT: a bad actor in fat makes good in liver Related research, protocols, and guides Explore the available research context, protocol variants or comparisons, and practical guides
B12 can help offset that
