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Effects of different fatty acids composition of phosphatidylcholine on brain function of dementia mice induced by scopolamine

Rmigy H-W

D.HedrickM.BettaiebA

5,10-MTHF reductase (5,10-MTHFR) carries out a central reaction in folate metabolism with the production of 5-MTHF, which is required for the biosynthesis of methionine, purine nucleotides, and thymidylate [17]

The glutathione pool in cell compartments containing a GR is highly reduced (50,000:1 GSH:GSSG), leaving only nM concentrations of glutathione disulfide (GSSG)

Another aspect of advanced neuronal degeneration is represented by ghost neurons, found in the ischemic core and in the ischemic penumbra zone, which exhibits an irregular and very ill-defined cell border, pale staining cytoplasm in H&E staining and pyknotic, dark nucleus