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Many of the B vitamins are involved in the recycling of glutathione (13)

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Toxicol Pathol 30(6):620650 Kovtun Y, Chiu WL, Tena G et al (2000) Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade

Generally a separation of 24 or more hours of any antioxidant IV (GSH, Nutrient IV followed by GSH etc.) allows plenty of time to have both the oxidative and anti-oxidative therapies work to maximum

Additionally, these reactive species induce DNA oxidation, leading to mitochondrial and nuclear DNA mutations, further impairing ATP production and exacerbating ETC dysfunction