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( E ) Volcano plot showing metabolite alterations in mouse livers following GSH depletion

The level of apoptosis was checked by flow cytometry-based Annexin V/PI

The inflammatory markers include C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) (Victor et al., 2015) and animal models (Rabah et al., 2023)

It is well-documented that both growth hormone and insulin-like hormone-1 decline with age , as many things do, and the causes are multifactorial

Liu Q, Wang K

Rosenblat, M., Volkova, N., Coleman, R