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SF has shown notable effects in mitigating inflammation and oxidative stress associated with SCI in mouse models

The evidence base for IBD and leaky gut is more preliminary but biologically plausible given the mechanism

Trends Endocrinol Metab 25(7):364373

Hippocampal Neuron-Enriched Cultures Primary neuronal cultures were established from 18-day-old embryonic rat hippocampi, as previously described ( 2 ) glass coverslips, previously coated with poly(D-lysine) (50 g/ml) and then with DMEM/HAM F12 containing 10% FCS

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Their high intake increases excitatory neurotransmission, generates ROS, and contributes to CNS oxidative stress [82]