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These are not separate from physical health

The release of Hb and Fe 2+ generates ROS harmful to dopaminergic neurons

doi: 10.1136/bmj.1.5687.11 536 HooperM

However, the PPS should always keep in mind that while a "hot-spot" approach makes sense to efficiently allocate and manage resources to where they will be needed most, the projects metrics will be measured based upon the entire PPS population attributed to that project
When researchers clipped off this tail and tested it on its own, they made a monumental discovery

Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation
