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Kirenol, a compound from Herba Siegesbeckiae, induces apoptosis in human chronic myeloid leukemia K562 cells

ROS are a group of chemically reactive molecules and free radicals that contain oxygen

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Experimental evidence indicates that polyphyllin VII (PPVII) treatment in bladder cancer cells markedly elevates intracellular and mitochondrial ROS levels, directly linking oxidative stress to mitochondrial apoptosis ( Increased ROS accumulation reduce mitochondrial membrane potential (m), thereby promoting cytochrome c release from mitochondria into the cytosol

Mishra KK, Pal RS, Chandrashekara C, Jain SK, Bhatt JC (2013) Antioxidant properties of different edible mushroom species and increased bioconversion efficiency of Pleurotus eryngii using locally available casing materials

Furthermore, these enzymes induce oxidative stress by modifying proteins through halogenation, nitration, and forming protein cross-links via tyrosyl radicals (Davies, 2011)
