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In contrast to GSH synthesis, which occurs intracellularly, GSH degradation occurs exclusively in the extracellular space, and in particular, on the surface of cells that express the enzyme -glutamyl transpeptidase (also called -glutamyl transferase, GGT

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Johnston, 2010)

The doses were selected from previous studies that demonstrated protective efficacy without toxicity (Mel) or included dose-response evaluation (GSH)

doi: 10.1371/journal.pone.0065475

established that after the left anterior descending coronary artery (LAD) ligation, Wnt11 expression in rat myocardial tissue significantly decreased in a time-dependent manner, while infarct size increased