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96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

doi: 10.1016/S0140-6736(05)67109-7

Activation of the receptor by GH binding was found to result in an increase in distance between the Box2 motifs of the intracellular receptor domains

This effect of RRM1 silencing on erastin2-induced ferroptosis was specific: RRM1 silencing did not inhibit cell death in response to several mechanistically distinct small molecule inducers of apoptosis or other forms of non-apoptotic cell death that are not directly linked to intracellular GSH metabolism (Ko et al, 2019) (Fig S4A)
