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Stahl SM, Felker A

doi: 10.1007/s12033-007-0052-y

The decreased activity of the ALDH2 2*2 variant stems from a single amino acid substitution, where lysine replaces glutamate, resulting in a 200-fold increase in the KM (which represents the affinity of an enzyme for its substrate) for NAD+ binding

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On the other hand, in the clinic we research the effectiveness of FPP with parameters widely known in medical and scientific fields

developed a model of Ox-LDL-induced ferroptosis in HUVECs, showing that CTRP13 intervention increased antioxidant enzyme expression, preventing AS and protecting endothelial cells from ferroptosis ( / mice by reducing mitochondrial damage, boosting glutathione and superoxide dismutase levels, and decreasing LPO and MDA levels