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Metformin can interfere with the absorption of vitamin B12 in the small intestine, leading to lower B12 levels over time

Because it looks the same to your body as Ghrelin, it has the same effect of turning down somatostatin and encouraging your body to secrete more GH

[DOI] [PubMed] [Google Scholar] 104.Albers J., Chaudhry V., Cavaletti G., Donehower R

While not establishing conclusive evidence, studies have consistently shown how raising vitamin B12 levels can positively impact depression symptoms

J Perinatol 37, 9197

[DOI] [PMC free article] [PubMed] [Google Scholar] 415.Wang Y., Guo J., Chen M., Liao S., Xu L., Chen Q., Song G., Zhang X.-B