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More recently, the antioxidant ebselen, which inhibits inositol monophosphatase and induces lithium-like effects on mouse behavior, was suggested as a safe alternative to lithium (Singh et al., 2013)

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-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function

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Many bioactive compounds exhibit antioxidant, anti-inflammatory, hormone-modulating, and barrier-stabilizing properties, providing a biologically plausible foundation for nutritional interventions (Figure 2)

This allows anti-inflammatory efficacy while maintaining a favorable safety margin