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BODIPY staining Cells were pre-treated with sardomozide for 96 h

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Zinc, which is essential for the formation of myelin and can induce oxidative stress in its own right, may be involved in the abnormal homeostasis of bioactive metals, which might play a role in Alzheimer's disease - zinc binds to amyloid precursor protein 57 and aluminium, zinc, iron, and copper directly bind to amyloid protein promoting its aggregation

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doi: 10.1038/cdd.2017.159 17 GuizeRLiuVMRosebrockDJourdainAAHernndez-SnchezMMartinez ZuritaAet al

Tau hyperphosphorylation may result from OS-mediated interaction with tau protein kinase and phosphatase, particularly GSK-3 and PP2A, the predominant enzymes regulating Tau metabolism