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Clinical trial studies demonstrated that low systemic bioavailability of curcumin is observed in human following oral administration

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, Munger J

Liver Int 2022;42:72941

Laryngoscope 125:11751182 Bustos PS, Deza-Ponzio R, Pez PL, Albesa I, Cabrera JL, Virgolini MB, Ortega MG (2016) Protective effect of quercetin in gentamicin-induced oxidative stress in vitro and in vivo in blood cells

These observations suggest that coupling dopamine to 3-PLG nanostructures did not alter the effective BBB penetration of A-GSH targeted 3-PLGs or entry to brain organoids