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In addition to SAM depletion, even inactive NNMT can interact with betaine-homocysteine methyltransferase (BHMT), methionine adenosyltransferase (MAT), and adenosylhomocysteinase (AHCY) to regulate methyl donor balance (96, 97)

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one survey cited that over 90% of patients reported improvements in their condition. However, responses vary, and injections should not be viewed as a cureall or substitute for a balanced diet, adequate sleep, and exercise

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