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These different scales can be used in combination to identify abnormalities or severity of different symptoms which may present in FRDA, and have been used in the clinical trials which tested the compounds discussed in this review paper

Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and serum glucose were measured by standard biochemical methodologies using British National Health Service (NHS) laboratory protocols ( Fasting lipid profiling Fasting serum lipids were measured using standard enzymatic methods

This transport process includes several steps ('carnitine shuttle'), which are described above for VPA [34, 35]

As for the geographical origin patients were included in one of the following regions: Western Europe, Eastern Europe and the Caucasus, Africa, Latin America and Asia