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doi: 10.24272/j.issn.2095-8137.2021.023 9 CrosiersD.TheunsJ.CrasP.Van BroeckhovenC

Parkinsonian neurotoxin MPTP and its toxic metabolite MPP + lead to neurodegeneration through mediating oxidative stress, neuroinflammation, and mitochondrial dysfunction

ProTox 3.0 software was used to predict the toxicity of the compounds (193) and the three drugs (allopurinol, febuxostat, and topiroxostat) [46]

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Objective sleep parameters accounted for close to 20% of the variance of subjective sleep ratings (over the effect of controls)

However, the most promising outcomes concern post-transfusion aspects: a drop was observed in fibrinogen subunit levels that could lead to minor aggregation, while recovery was increased, satisfying the gold standard of transfusion therapy (Hicks et al., 2024)