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Animal studies also show that regular HIIT can modulate the activation of monocyte-macrophages in muscle tissue, reducing M1 macrophages and increasing M2 macrophages (111), while also reversing high-fat diet-induced M1 polarization and further promoting M2 polarization, thereby improving metabolic and immune status (112)

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Autophagy has been proposed as an inhibitor of tumor initiation by removing damaged proteins and organelles, protecting cells from reactive oxygen species (ROS), necrosis, inflammation, genomic instability, and metabolic alterations [107]

So, we may have a longer-lasting energy source to push us for a bit longer at high intensities

Y., Sohn, K

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