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Thus, PARPs and sirtuins in the same subcellular compartmentation have counterbalancing roles in the regulation of NAD + homeostasis [55]

Kurtdede, A

[DOI] [PubMed] [Google Scholar] Shipton, M

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This intersection between TGF-1 signaling, redox imbalance, and immune dysregulation underscores the multifaceted role of the cytokine in sustaining the systemic, multi-organ pathology characteristic of CIRS