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In a mouse model, the effects are seen much sooner in epidermis than the effects seen in the connective tissue with accelerated aging phenotypes (e.g., weight loss, skin atrophy, kyphosis, osteoporosis, muscle degeneration. [7] When ROS levels are too high, it will cause senescence as previously mentioned and also a feedback loop that will cause more senescence

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It serves as a cofactor for glutathione peroxidases, and is involved in the regulation of the nitric oxide cycle

Inhibition of TRPA1 attenuates oxidative stress-induced damage after traumatic brain injury via the ERK/AKT signaling pathway

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