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These compounds promote increased extracellular glycine in the central nervous system, leading to the recovery of spinal inhibitory glycinergic function, which is important for pain control

doi:10.1038/srep08506

& Sorscher, E

[88] reported that the diurnal expression of Klf4 was lower in aged macrophages than in young macrophages and that the loss of Klf4 expression was accompanied by circadian rhythm disruption in the phagocytic activity of macrophages, indicating that the circadian rhythm was associated with agingrelated changes in macrophage phagocytosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Bhutia YD, Ganapathy V

The Glia/Neuron Ratio: How It Varies Uniformly Across Brain Structures and Species and What That Means for Brain Physiology and Evolution. Glia 62: 13771391