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J Clin Endocrinol Metabol 94(12):49614970 Ambati RR, Ramadan MF (2021) Nigella sativa Seed extracts in functional foods and nutraceutical applications

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Peroxisomal -oxidation degrades very-long-chain fatty acids, with its dysfunction causing lipotoxic mediator accumulation (e.g., ceramides) that induce oxidative stress and aberrant inflammatory signaling (89,90)