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(1) Microglia become overwhelmed and cannot keep up with demand, and/or (2) shift into a less sensitive state trying to keep inflammatory signals to a minimum by reducing their reactivity to endogenous ligands (Hickman et al., 2013)

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Ghorbani M, Azghandi M, Khayami R, Baharara J, Kerachian MA

Targeting CD38 to suppress osteoarthritis development and associated pain after joint injury in mice