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A biphasic inotropic effect has also been reported across a range of LCAC doses, species, and tissue preparations

Work from our and other groups showed that LAC also modulates acetylation of NF-B/p65 subunit, which potentiates the transcriptional activity of NF-B member to increase transcription of the Grm2 gene encoding for the mGlu2 receptor in hippocampus and prefrontal cortex of FSL rats [30, 36]

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