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To better define statin anticancer activity, we interrogated the ability of the seven most commonly prescribed statins to induce cell death and ferroptosis in melanoma and colorectal cancer cell lines

Following up on this clinical efficacy trial, we have begun a pragmatic cluster randomized trial that will examine the clinical effectiveness of the 5-Cog paradigm, including the critical aspect of integration of results with recommendations for follow-up in the EMR, in 22 primary care clinics as well as evaluate implementation issues and economic impact (NCT05515224)