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Clinical trials involving over 900 participants showed AOD-9604 to be well-tolerated with side effects indistinguishable from placebo in most studies

Furthermore, according to a randomized trial conducted in a population of patients with T2D receiving metformin for at least 4 years and experiencing diabetic neuropathy, administration of 1 mg oral methylcobalamin for 1 year was associated with a significant improvement in neurophysiological parameters and scores assessing neuropathic pain and quality of life [58]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Smelt H.J.M., Pouwels S., Smulders J.F

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Table: Effects of Vitamin B12 on Homocysteine Metabolism Interaction with Anticoagulant Medications Heart patients on blood thinners should be careful with B12 supplements