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Description
High NNMT exacerbates cell oxidative stress and apoptosis, worsening disease progression
Zadra, G
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By inhibiting the NNMT enzyme, it prevents the excessive consumption of NAD+, a critical molecule that your cells need for energy production, DNA repair, and maintaining healthy metabolic function
In fat cells, 5-amino-1MQ lowered the NNMT byproduct 1-methylnicotinamide (EC50 near 2.3 micromolar) and cut fat storage, without disturbing the other enzymes in the NAD+ salvage pathway
Studies have shown that knocking down the NNMT gene leads to increased expenditure of energy in adipocytes (Xu et al., 2022)
