glutathione polmorphism and apoe e4 Apolipoprotein E Alzheimer's disease A multi‐hit hypothesis for an

10.1016/0261-5614(91)90039-F 131

Functionally analogous are the Peroxiredoxins (Prx) , which use the same mechanism but with a cysteine active site that shuttles from the thiolate (S-H) to the sulphinic acid (S-OH) form and is reduced back by glutathione

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The uPFK-2 isoform has the highest kinase to bisphosphatase activity ratio indicating this version of PFK-2 favors the glycolytic direction

doi: 10.1021/es0346680 151 YuQ.MishraB.FeinJ

We speculate that a systemic increase in GSH in diabetic patients resulted in a significant reduction in oxidative DNA damage, improved the pancreatic -cell function, and concomitantly reduced HbA1c, prominently so in elderly diabetic individuals