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Oral administration of pregabalin (at a target dose of 150 mg/day in three divided doses, much less than gabapentin) significantly reduced the severity of sensory neuropathy induced by oxaliplatin by 1-2 grades

& Zhou, B

The pharmacokinetic properties including intestinal permeability, first-pass metabolism, microbiota-mediated biotransformation, plasma half-life, and systemic availability is essential for translational relevance

This hypothesis was based on sequence similarity between ACO and a tomato cysteine protease (Matarasso et al., 2005), and the strongly conserved C28 as a key residue in the active site of this protease (Dilley et al., 2013)

Prez, F

, Motaal, A