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This intracellular accumulation of FFAs and their esterified products, such as diacylglycerols and triglycerides, initiates lipotoxicity

During this process, a small fraction of proliferating myoblasts return back to quiescence to replenish the stem cell pool 9

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Hou X., Zaks T., Langer R., and Dong Y., Lipid Nanoparticles for mRNA Delivery, Nature Reviews Materials 6 (2021): 10781094

The enrichment of genes associated with regional emphysema severity with COPD-related phenotypes in these other datasets suggests that the biological processes associated with increasing emphysema severity within a patient with severe COPD also vary in individuals with earlier stages of disease
