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The genes for mitobiogenesis and mitophagy were downregulated when both Mfn1 and Mfn2 were removed in midgestational and postnatal cardiac myocytes, and the mice went on to develop cardiomyopathy and died within 16 days of birth [244]

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The ethacrynic acid moiety of the conjugate binds in the H site in a fashion that has not been observed in crystal structures of other glutathione-based inhibitor complexes

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A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

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