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In fact, more than 5,000 distinct phytochemical compounds have been identified in grains, vegetables, and fruits, many of which act as secondary metabolites with therapeutic potential (121, 122)

The temporal sequence and regulation of HIF-1-dependent downstream proteins play a crucial role in the pathogenesis and recovery of stroke, potentially affecting the balance between inflammatory and angiogenetic responses

At least two studies suggest that SFs neuroprotection may stem from decreased BBB permeability, improved cell survival, and/or enhanced aquaporin-4 (AQP4) channel presence

MOTS-c: a promising mitochondrial-derived peptide for therapeutic exploitation

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utilized copper oxide nanoparticles (CuONPs) to treat murine macrophages and observed increased levels of proteins and mRNA, such as NLRP3, Caspase-1, and IL-1, as well as increased IL-1 release