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doi: 10.2174/1566524022666220525144630 72 MaLHeYXieHWangJChenJSongSet al

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The activation of the IGF-1R leads to a signaling cascade involving the phosphatidylinositide 3-kinase (P13K) and mitogen-activated protein kinase (MAPK) pathways that lead to cell survival and proliferation, which ultimately result in bone elongation (Figure 3)

[DOI] [PMC free article] [PubMed] [Google Scholar] [129].Doll S, Proneth B, Tyurina YY, et al

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TNF- inhibitors are currently the most commonly used biologics, and TNF- blockade has become the central strategy of targeted antiinflammatory therapy in the disease (McInnes & Schett, 2011
