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One reason for this might be the fact that we only analyzed extracellular nutrient levels, and at least for magnesium, this might influence the outcome

Consistency matters with long-acting peptides

PMC5826726

This analysis excluded trials in those with end-stage renal disease, who are at high risk of cardiovascular events and mortality
[4] Clinical assessment should focus on identifying the cause of elevated levels rather than assuming toxicity from supplementation alone

Relevant if that applies to your research context
