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Dopamine oxidation, through the endogenous production of various neurotoxic metabolitessuch as dopamine quinones and thio-catecholaminestriggers a cascade of molecular events leading to cell death, with a high specificity for dopaminergic neurons in the substantia nigra

Overall, the developed DRG organoid system represents a valuable platform for modeling and testing therapeutic interventions for FRDA and other pathologies affecting the peripheral nervous system

592 In summary, inhibition or activation of fundamental pathological interactions presents an alternative therapeutic avenue for AD

Farhat Z, Browne RW, Bonner MR, Tian L, Deng F, Swanson M, Mu L (2018) How do glutathione antioxidant enzymes and total antioxidant status respond to air pollution exposure

Key pathways such as PI3K-AKT-mTOR, LKB1-AMPK, E-cadherin-Hippo-YAP/TAZ, and VHL-HIF critically modulate ferroptosis in cancers via metabolic regulation and stress-response mechanisms ( In the future, integrating strategies to target ferroptosis defense pathways and enhance the efficacy of cancer immunotherapy will represent a promising therapeutic approach

Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension