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This study revealed that 21% of the investigated cohort of ASD patients carried mtDNA or nuclear DNA (nDNA) mutations related to mitochondrial dysfunction

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While ETC activity drives pro-ferroptotic ROS generation via electron leakage, it is also essential for anti-ferroptotic enzymes (e.g., DHODH and GPD2) that reduce mitochondrial coenzyme Q (CoQ) to ubiquinol (CoQH 2 ) (113115)