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En lugar de centrarse en suplir un compuesto especfico, el enfoque se orienta hacia la optimizacin del contexto biolgico en el que este se produce y se utiliza
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Succinate : Accumulation stabilizes Hypoxia-Inducible Factor-1 (HIF-1), driving pro-inflammatory gene expression in macrophages (e.g., IL-1) (37)
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