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The metabolic pathway from obesity to liver fat MASLD begins when hepatocytes accumulate triglyceride because the delivery and synthesis of fatty acids outpace their oxidation and export
2004 Apr;5(4):43640
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As a result, testes stop producing testosterone, leading to low endogenous testosterone levels, low sperm count and eventually infertility
This process, often referred to as target validation , is a foundational step in early drug development
