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Furthermore, as mentioned previously, bacteria are far too large and lipophilic to be transported via the paracellular pathway, even in the presence of inflammation [42, 72]

IV administration achieves higher plasma levels acutely, but cellular tissue penetration and long-term benefit remain unclear

Smaller studies by Georgiades et al

Greene, L

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These studies demonstrated that maintaining cystine homeostasis within cells is essential for cell survival, as cystine deficiency causes ferroptosis, and excessive cystine accumulation leads to disulfidptosis