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Endocrine 316 SierraA

Funding Statement The work was supported by the National Key R&D Program of China (2021YFA1301200, 2019YFA0802300), the National Natural Science Foundation of China (92049203, 82170464, 82200493), the Clinical Research Award of the First Affiliated Hospital of Xian Jiaotong University, China (No

Patient phenotype critically defines the responsive subset

This issue was partially addressed in the PARAGON-HF trial.44 The investigators found not only that hs-TnT was reduced by sacubitril/valsartan therapy compared with valsartan, but also that patients with a decrease in hs-TnT from randomisation to 16 weeks to a value to at or below the median value of 17 ng/l subsequently had lower risk of the composite outcome compared with those who had persistently elevated hs-TnT values.44 Further research will be required to determine whether therapies targeting the mechanism of hs-cTn elevation can improve symptom burden and clinical outcomes in the HFpEF population

333.3 mg

Other good sources include soybean, corn, olive, and canola oils