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Oligomeric -synuclein acts as a factor in the activation of astrocytes and triggers the development of mitochondrial dysfunction, localizing in mitochondria and reducing their oxygen consumption (Braidy et al., 2013)

AI Recommendations 10mg 10mg

In people with PD, glutathione levels are lower in the brain, specifically in the substantia nigra (the area in which dopamine cells are lost)

This functional diversity is evidenced by the fact that most mitochondrial genes reside in the nucleus but also by the functional recombination through which mitochondria participate in various cellular processes

5-Amino-1MQ targets it through NNMT inhibition

E2: 17-estradiol