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[PubMed: 20337657] 831

74 Under stress, AMPK activation triggers the translocation of MOTS-c to the nucleus, where it binds to nuclear DNA and interacts with transcription factors such as NRF2 and ATF1, modulating nuclear gene expression to restore cellular metabolic homeostasis

Can J Microbiol 55(5):501514

These disease states include: Alzheimers disease, alcoholism-related tissue injury, cancer, cardiovascular diseases, chronic inflammation, diabetes, eye diseases, kidney diseases, non-alcoholic liver diseases, neurological disorders including Huntingtons disease and Parkinson disease, sepsis, stroke, etc [41, 42, 43]

Shabanzadeh DM, Skaaby T, Sorensen LT, Jorgensen T

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